Food is fundamental to life. Yet, our eating habits have become incredibly complex, involving many aspects of daily life far beyond addressing simple nutritional needs. Our world is characterized by environments that promote increased consumption of unhealthy food and sedentary lifestyles; over-nutrition and obesity now surpass under-nourishment as the world’s leading food and nutrition problem. Through this multi-media exhibit, visitors will explore all aspects of the challenge that faces us in the 21st century. Big Food will begin with the neuroscience of appetite, genetics of obesity, and how food and energy are stored in the body. It will examine behavioral choice in nutrition and exercise as well as the influence of social, environmental, and cultural settings. Using an engaging multi-media and family-friendly approach, visitors will investigate our origins as hunter-gatherers; explore societal pressures such as the progressive growth of portion sizes; tackle media influences on food preferences; and consider serious health consequences that have increased the burden of chronic diseases, including diabetes and heart disease.